We then assessed global and local genetic correlations and statistical colocalisation between depression/depression symptoms and AD across six AD GWAS with varying proportions of clinical and proxy (family history) case ascertainment. Using data from the UK Biobank, the GLAD Study and PROTECT, we performed the largest genome-wide meta-analyses (GWAS) of the nine depression symptom items, plus their sum score, on the Patient Health Questionnaire (PHQ-9) (GWAS equivalent N: 224,535–308,421).
Assessing depression symptom specific genetic associations may better clarify this relationship. Lewis, View ORCID Profile Petroula Proitsi, AddNeuroMed, GERAD1 Consortium the Alzheimer’s Disease Neuroimaging Initiativeĭepression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for their genetic relationship is mixed.
Eley, View ORCID Profile Gerome Breen, View ORCID Profile Alfredo Iacoangeli, Sulev Koks, View ORCID Profile Cathryn M. Davies, View ORCID Profile Christopher Hübel, View ORCID Profile Shannon Bristow, View ORCID Profile Sang Hyuck Lee, View ORCID Profile Henry Rogers, View ORCID Profile Charles Curtis, View ORCID Profile Gursharan Kalsi, View ORCID Profile Ryan Arathimos, View ORCID Profile Anne Corbett, View ORCID Profile Clive Ballard, View ORCID Profile Helen Brooker, View ORCID Profile Byron Creese, View ORCID Profile Dag Aarsland, Adam Hampshire, View ORCID Profile Latha Velayudhan, View ORCID Profile Thalia C. Davies, View ORCID Profile Jessica Mundy, View ORCID Profile Molly R. Thorp, View ORCID Profile Brett Adey, View ORCID Profile Jodie Lord, Helena L. Or you too shall be counted amongst those lost forever.View ORCID Profile Lachlan Gilchrist, View ORCID Profile Thomas P. But beĪware that should the sword fail, you have the magical arts to Your sword arm well to rid the land of a potent curse. Strong enough to face the minions of death, and wise enough toįollow the path that leads to the essence of light. Imagination await the warrior bold enough to attempt the journey, Monsters fear the evil that has returned. Is a palpable fear in the air of the Ancient City.
You must return the idol to the Ancient City to break itsĬurse, but monsters of unspeakable horror haunt the ruins. Race has resurfaced to wreak havoc once again among the kingdoms Imported from UK (Sizes & Specifications are based on the UK Market).Īn accursed idol responsible for the destruction of an ancient.About this item An accursed idol is responsible for the destruction of an ancient race You must return the idol to the Ancient City to break its curse Monsters, however, are opposed to your course of action Use your sword and magic to bring victory home A sprawling fantasy adventure.
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